James H. Schofield (g), Joseph Longo, Ryan Sheldon, Emma Albano (u), Abigail E. Ellis, Mark A. Hawk (g), Sean Murphy, Loan Duong, Sharif Rahmy, Xin Lu, Russell G. Jones, Zachary T. Schafer. Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides. Cell Rep. 2024 Mar 22;43(4):113984. Link for Full Text.

Sean Murphy, Sharif Rahmy, Dailin Gan, Gioqiang Liu, Yini Zhu, Maxim Manyak, Loan Duong, Jianping He (p), James H. Schofield (g), Zachary T. Schafer, Jun Li, Xuemin Lu, Xin Lu. Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy. Cancer Res. 2024 Apr 8. doi: 10.1158/0008-5472. Link for Full Text.

Jason Rodencal, Nathan Kim, Andrew He, Veronica L. Li, Mike Lange, Jianping He (p), Amy Tarangelo, Zachary T. Schafer, James A. Olzmann, Jonathan Z. Long, Julien Sage, and Scott J. Dixon. Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest. Cell Chem Biol. 2024 Feb 15;31(2):234-248. Link for Full Text.

Hannah Gordon, Zachary T. Schafer, Cody J. Smith. A paradox promoted by microglia cannibalism shortens the lifespan of developmental microglia. bioRxiv. 2023 March. Link for Full Text.

Lisa M. Hom(g), Seunghoon Sun(u), Jamie Campbell(u), Pinyan Liu, Shannon Culbert(u), Ireland M. Murphy(u), and Zachary T. Schafer. A role for fibroblast-derived SASP factors in the activation of pyroptotic death in mammary epithelial cells. J Biol Chem. 2023 Jun 13;:104922. Link for Full Text.

James H. Schofield(g) and Zachary T. Schafer. Regulators Mount Up: The Metabolic Roles of Apoptotic Proteins. Front Cell Death. 2023 July. 2:1223926. Link for Full Text.

Jianping He(p), Abigail M. Abikoye(u), Brett P. McLaughlin(u), Ryan S. Middleton(u), Ryan Sheldon, Russell G. Jones, and Zachary T. Schafer. Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells. iScience. 2023 May 9;26(6):106827. Link for Full Text.

Lisa M. Hom(g) and Zachary T. Schafer. Assessment of metabolic pathways and parameters in extracellular matrix-detached cells. Methods Mol Biol. 2023;2675:309-315. Link for Full Text.

Matyas Abel Tsegaye(g), Jianping He(p), Kyle McGeehan(u), Ireland M. Murphy(u), Mati Nemera(u), and Zachary T. Schafer. Oncogenic signaling inhibits c-FLIP expression and promotes cancer cell survival during ECM-detachment. Sci Rep. 2021 Sep 20;11(1):18606. Link for Full Text.

Joshua A. Mason(g), Jordan A. Cockfield(g), Daniel J. Pape(u), Hannah Meissner(u), Michael Sokolowski(u), Taylor C. White, José C. Valentín López, Juan Liu, Xioajing Liu, Inmaculada Martinez-Reyes, Navdeep S. Chandel, Jason W. Locasale, and Zachary T. Schafer. SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells. Cell Rep. 2021 Mar 16;34(11):108821. Link for Full Text.

James H. Schofield(g) and Zachary T. Schafer. Mitochondrial Reactive Oxygen Species and Mitophagy; A Complex and Nuanced Relationship. Antioxid Redox Sign. 2021 Mar 1;34(7):517-530. Link for Full Text.

Yanting Luo, Louise Medina Bengtsson, Xuechun Wang, Tianhe Huang, Guoqiang Liu, Sean Murphy, Caiqin Wang, John Koren III, Zachary Schafer, and Xin Lu. UQCRH downregulation promotes Warburg effect in renal carcinoma cells. Sci Rep. 2020 Sep 14;10(1):15021. Link for Full Text.

Jordan A. Cockfield(g) and Zachary T. Schafer. Antioxidant defenses: a context-specific vulnerability of cancer cells. Cancers (Basel). 2019 Aug 20;11(8). Link for Full Text.

Mark A. Hawk(g), Cassandra L. Gorsuch(g), Patrick Fagan(u), Chan Lee, Sung Eun Kim, Jens C. Hamann, Joshua A. Mason(g), Kelsey J. Weigel(g), Matyas Abel Tsegaye(g), Luqun Shen(u), Sydney Shuff, Junjun Zuo, Stephan Hu(u), Lei Jiang, Sarah Chapman, W. Matthew Leevy, Ralph J. DeBerardinis, Michael Overholtzer, and Zachary T. Schafer. RIPK1-Mediated Induction of Mitophagy Compromises the Viability of Extracellular Matrix-Detached Cells. Nat Cell Biol. 2018 Mar; 20(3):272-284. Link for Full Text.

Mark A. Hawk(g) and Zachary T. Schafer. Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment. J Biol Chem. 2018 May 18;293(20):7531-7537. Link for Full Text.

Joshua A. Mason(g), Kimberly R. Hagel(t), Mark A. Hawk(g), and Zachary T. Schafer. Metabolism during ECM-Detachment: Achilles Heel of Cancer Cells? Trends Cancer. 2017 Jul;3(7):475-481. Link for Full Text.

Joshua A. Mason(g), Calli A. Davison-Versagli(g), Amy K. Leliaert(t), Daniel J. Pape(u), Chelsea McCallister(g), Junjun Zuo, Sienna M. Durbin(u), Cassandra L. Buchheit(g), Siyuan Zhang, and Zachary T. Schafer. Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death Differ. 2016 Aug;23(8):1271-82. Link for Full Text.

Cassandra L. Buchheit(g), Brittany L. Angarola(u), Allison Steiner(u), Kelsey J. Weigel(g), and Zachary T. Schafer. Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration. Cell Death Differ. 2015 Aug; 22(8): 1275-86. Link for Full Text.

Raju R. Rayavarapu(g), Brendan Heiden(u), Nicholas Pagani(u), Melissa M. Shaw(u), Sydney Shuff, Siyuan Zhang, and Zachary T. Schafer. The Role of Multicellular Aggregation in the Survival of ErbB2-Positive Breast Cancer Cells during Extracellular Matrix-Detachment. J Biol Chem. 2015 Apr 3;290(14):8722-33. Link for Full Text.

Cassandra L. Buchheit(g), Kelsey J. Weigel(g), and Zachary T. Schafer. Cancer Cell Survival During ECM-Detachment: Multiple Barriers to Tumor Progression. Nat Rev Cancer. 2014 Sep;14(9):632-41. Link for Full Text.

Kelsey J. Weigel(g), Ana Jakimenko(p), Brooke A. Conti(u), Sarah E. Chapman, William J. Kaliney, W. Matthew Leevy, Matthew M. Champion, and Zachary T. Schafer. CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis. Mol Cancer Res. 2014 Jun; 12(6): 855-66. Link for Full Text.

Calli A. Davison(g), Sienna M. Durbin(u), Matthew R. Thau(u), Victoria R. Zellmer(u), Sarah E. Chapman, Justin Diener, Connor Wathen, W. Matthew Leevy, and Zachary T. Schafer. Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix. Cancer Res. 2013 Jun 15; 73(12): 3704-15. Link for Full Text.

Arkaitz Carracedo, Dror Weiss, Amy K. Leliaert(t), Manoj Bhasin, Vincent C. J. deBoer, Gaelle Laurent, Andrew Adams, Maria Sundvall, Su Jung Song, Keisuke Ito, Lydia S. Finley, Ainara Egia, Towia Libermann, Zachary Gerhart-Hines, Pere Puigserver, Marcia C. Haigis, Elefteria Maratos-Flier, Andrea L. Richardson, Zachary T. Schafer, and Pier P. Pandolfi.  A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep 4;122(9):3088-100. Link for Full Text.

Alexandra R. Grassian, Zachary T. Schafer, and Joan S. Brugge. Regulation of Epidermal Growth Factor Receptor and β1 Integrin Expression by ErbB2 and Extracellular Matrix. J Biol Chem. 2011 Jan 7;286(1):79-90. Link for Full Text.

Zachary T. Schafer, Alexandra R. Grassian, Loling Song, Zhenyang Jiang,  Zachary Gerhart-Hines, Hanna Y. Irie, Sizhen Gao, Pere Puigserver, and Joan S. Brugge. Antioxidant and Oncogene Rescue of Metabolic Defects Caused by Loss of Matrix Attachment. Nature. 2009 Sep 3;461(7260):109-13. Link for Full Text.

Zachary T. Schafer and Sally Kornbluth. The Apoptosome: Phyiological, Developmental, and Pathological Modes of Regulation. Dev Cell. 2006 May; 10(5): 549-561. Link for Full Text.

Zachary T. Schafer, Amanda B. Parrish, Kevin M. Wright, Seth S. Margolis, Jeffrey R. Marks, Mohanish Deshmukh, and Sally Kornbluth. Enhanced Sensitivity to Cytochrome c-Induced Apoptosis Mediated by PHAPI in Breast Cancer Cells. Cancer Res. 2006 Feb 15; 66(4): 2210-2218. Link for Full Text.